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Proteintech
KCNMA1 Polyclonal Antibody
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产品信息
22158-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KCNMA1 fusion protein Ag17802
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: KREWETLHNF PKVSILPGTP LSRADLRAVN INLCDMCVIL SANQNNIDDT SLQDKECILA SLNIKSMQFD DSIGVLQANS QGFTPPGMDR SSPDNSPVHG MLRQPSITTG VNIPIITELV NDTNVQFLDQ DDDDDPDTEL YLTQPFACGT AFAVSVLDSL MSATYFNDNI LTLIRTLVTG GATPELEALI AEENALRGGY STPQTLANRD RCRVAQLALL DGPFADLGDG GCYGDLFCKA LKTYNMLCFG IYRLRDAHLS TPSQCTKRYV ITNPPYEFEL VPTDLIFCLM QFDHNAGQSR ASLSHSSHSS QSSSKKSSSV HSIPSTANRQ NRPKSRESRD KQKYVQEERL
靶标信息
Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: big potassium channel alpha subunit; BK channel; BK channel alpha subunit; BKCA alpha; BKCA alpha subunit; calcium-activated potassium channel alpha subunit; Calcium-activated potassium channel subunit alpha-1; Calcium-activated potassium channel, subfamily M subunit alpha-1; K(VCA)alpha; KCa1.1; Maxi K channel; maxi-K channel HSLO; MaxiK; mSlo1; potassium channel, calcium activated large conductance subfamily M alpha, member 1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1; Slo homolog; Slo-alpha; Slo1; Slowpoke homolog; stretch-activated Kca channel
基因别名: 5730414M22Rik; bA205K10.1; BKCa; BKTM; hSlo; KCa1.1; KCNMA; KCNMA1; KCNMA1b; KCNMA1c; MaxiK; mSlo; mSLO1; SAKCA; SLO; SLO-ALPHA; SLO1
UniProt ID: (Human) Q12791, (Mouse) Q08460, (Rat) Q62976
Entrez Gene ID: (Human) 3778, (Mouse) 16531, (Rat) 83731
actin binding
voltage-gated potassium channel activity
protein binding
calcium-activated potassium channel activity
metal ion binding
large conductance calcium-activated potassium channel activity
ion channel activity
voltage-gated ion channel activity
potassium channel activity
protein complex binding
protein homodimerization activity
ion channel
response to hypoxia
potassium ion transport
response to osmotic stress
cellular potassium ion homeostasis
response to carbon monoxide
regulation of ion transmembrane transport
regulation of membrane potential
positive regulation of apoptotic process
negative regulation of cell volume
response to calcium ion
micturition
smooth muscle contraction involved in micturition
potassium ion transmembrane transport
transport
ion transport
chemical synaptic transmission
sensory perception of sound
circadian rhythm
adult walking behavior
response to pH
neuronal action potential
response to corticosteroid
regulation of aldosterone metabolic process
vasodilation
regulation of vasodilation
auditory receptor cell differentiation
response to estrogen
locomotor rhythm
saliva secretion
cell maturation
neuromuscular process controlling balance
protein homooligomerization
protein homotetramerization
transmembrane transport
eye blink reflex
relaxation of vascular smooth muscle
