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Invitrogen
KCNMA1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-33871
产品规格
种属反应
Bovine,
Dog,
Chicken,
Hamster,
Human,
Mouse,
Non-human primate,
Pig,
Rabbit,
Rat,
Xenopus,
Zebrafish
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 15 amino acid peptide from internal region of human KCNMA1.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.8 mg/mL
规格
50 µg
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: big potassium channel alpha subunit; BK alpha; BK channel; BK channel alpha subunit; BKCA alpha; BKCA alpha subunit; bSlo; calcium activated potassium channel protein; calcium-activated potassium channel alpha subunit; Calcium-activated potassium channel subunit alpha-1; calcium-activated potassium channel, subfamily M subunit alpha-1; gp90; env; hypothetical protein; k(VCA)alpha; KCa1.1; large conductance calcium-activated potassium channel alpha subunit; maxi K channel; maxi K channel; KCNMA1; maxi-K channel alpha subunit; maxi-K channel HSLO; maxi-k channel isoform; maxiK; MaxiK alpha subunit; MaxiK calcium-activated potassium channel; mSlo; potassium channel; potassium channel, calcium activated large conductance subfamily M alpha, member 1; potassium ion channel; potassium large conductance calcium-activated channel, subfamily M, alpha member 1; rbSlo; slo; slo homolog; slo-alpha; slo1; slowpoke; slowpoke homolog; splice variant; stretch-activated Kca channel; unnamed protein product; voltage-sensitive calcium channel
基因别名: 5730414M22Rik; bA205K10.1; BKCA; BKCA alpha; BKTM; CADEDS; cbv1; cSlo; hSlo; I79_002194; IEG16; k(VCA)alpha; KCa1.1; KCNMA; KCNMA1b; KCNMA1c; LIWAS; MaxiK; mSlo; mSLO1; PNKD3; RBSLO1; SAKCA; SLO; SLO-ALPHA; SLO1
voltage-gated ion channel activity
protein binding
metal ion binding
large conductance calcium-activated potassium channel activity
actin binding
ion channel activity
voltage-gated potassium channel activity
calcium-activated potassium channel activity
identical protein binding
potassium channel activity
macromolecular complex binding
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
ion channel
regulation of ion transmembrane transport
potassium ion transmembrane transport
relaxation of vascular smooth muscle
positive regulation of membrane hyperpolarization
response to hypoxia
ion transport
potassium ion transport
response to osmotic stress
cellular potassium ion homeostasis
response to carbon monoxide
vasodilation
regulation of membrane potential
positive regulation of apoptotic process
negative regulation of cell volume
response to calcium ion
transmembrane transport
micturition
smooth muscle contraction involved in micturition
chemical synaptic transmission
sensory perception of sound
circadian rhythm
adult walking behavior
neuronal action potential
regulation of aldosterone metabolic process
auditory receptor cell differentiation
locomotor rhythm
saliva secretion
cell maturation
neuromuscular process controlling balance
protein homooligomerization
eye blink reflex
response to pH
positive regulation of neuron apoptotic process
response to estrogen
negative regulation of smooth muscle contraction
regulation of blood vessel diameter
regulation of presynaptic membrane potential
negative regulation of small intestine smooth muscle contraction
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