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OriGene
KCTD13 Monoclonal Antibody (OTI3B12), TrueMAB™
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产品信息
CF808801
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI3B12
抗原
Full length human recombinant protein of human KCTD13 produced in E.coli.
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 8% trehalose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
靶标信息
Cytochrome P450 super family proteins are monooxygenases which catalyze multiple biochemical reactions involved in drug metabolism and synthesis of cholesterol, steroids and lipids. CYP4F3, a 60KDa protein, is a novel member of this family. It consists of a conserved heme-binding domain near the C-terminus and catalyzes the u-hydroxylation of LTB4. CYP4F3 is localized in the ER and plays a vital role in the inactivation of LTB4 and controlling inflammation. CYP4F3 exists in two functionally distinct isoforms: CYP4F3A, a neutrophil isoform, is particularly expressed in neutrophils and myeloid cells and catalyzes the microsomal u-hydroxylation of LTB4. It interacts with CD11b and myeloperoxidase on myeloid cells and regulates cellular development in bone marrow. CYP4F3B, a liver isoform, catalyzes the conversion of arachidonic acid to 20-HETE, a potent activator of PKC. Itrole hasbeen implicatedin cell proliferation, vascular tone and natriuresis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; BTB/POZ domain-containing protein KCTD13; CTD-2574D22.4; hBACURD1; PDIP1; Polymerase delta-interacting protein 1; potassium channel tetramerisation domain containing 13; TNFAIP1-like protein; tumor necrosis factor alpha-inducible protein PDIP1
基因别名: 1500003N18Rik; AV259508; BACURD1; FKSG86; hBACURD1; KCTD13; PDIP1; PDIP1alpha; POLDIP1; PP6832
UniProt ID: (Human) Q8WZ19, (Mouse) Q8BGV7
Entrez Gene ID: (Human) 253980, (Mouse) 233877, (Rat) 293497
DNA replication
cell migration
protein ubiquitination
negative regulation of Rho protein signal transduction
stress fiber assembly
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of DNA replication
protein homooligomerization
DNA repair
regulation of transcription, DNA-templated
actin cytoskeleton organization
protein heterooligomerization
