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Invitrogen
KCTD19 Polyclonal Antibody
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产品信息
PA5-62774
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: KYPSLVTEDN LLWLAETVAL IECECSEFRF IVNFLRSQKI LLPDNFSNID VLEAEVEILE IPALTEAVRW YRMNMGGCSP TTCSPLSPGK GARTASLESV KPLYTMALGL LVKYPDS
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 91%.
靶标信息
The KCTD19 (Potassium Channel Tetramerization Domain Containing 19) gene encodes a protein that plays a crucial role in meiotic chromosome organization and male fertility. KCTD19 is located on chromosome 5 in humans. The protein is known to interact with zinc finger protein 541 (ZFP541) and histone deacetylase 1 (HDAC1), highlighting its role in chromatin organization and transcription regulation during meiosis. Mutations or loss-of-function variants in KCTD19 have been implicated in non-obstructive azoospermia (NOA) and male infertility, as evidenced by studies in both human and mouse models. The gene's function in regulating the individualization of meiotic chromosomes is critical, and disruptions can lead to severe meiotic defects and spermatogenic failure.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BTB/POZ domain-containing protein KCTD19; potassium channel tetramerisation domain containing 19; Potassium channel tetramerization domain-containing protein 19; testicular tissue protein Li 101
基因别名: KCTD19
UniProt ID: (Human) Q17RG1
Entrez Gene ID: (Human) 146212
