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Invitrogen
KIF2A Polyclonal Antibody
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产品信息
PA5-110684
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: DNESVTVEWI ENGDTKGKEI DLESIFSLNP DLVPDEEIEP SPETPPPPAS SAKVNKIVKN RRTVASIKND PPSRDNRVVG SARARPSQFP EQSSSAQQNG SVSDISPVQA
Highest antigen sequence indentity to the following orthologs: Rat - 94%, Mouse - 92%.
靶标信息
KIF2A, a gene encoding the kinesin family member 2A protein, plays a pivotal role in neuronal development and function. This gene is part of the kinesin-13 subfamily, characterized by its unique ability to depolymerize microtubules, which are essential components of the cytoskeleton responsible for maintaining cell shape, enabling motility, and facilitating intracellular transport. KIF2A is particularly significant in neural settings, where it regulates microtubule dynamics crucial for neuronal migration and dendritic development. Dysfunctional KIF2A, due to mutations, has been linked to early-onset neurodegenerative diseases such as progressive microcephaly and mental disabilities due to impaired microtubule regulation, reflecting its foundational role in correct brain development and architecture. Additionally, KIF2A is involved in spindle assembly and chromosome segregation during cell division, further cementing its importance in both neurodevelopment and general cellular functions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hK2; kif2a {ECO:0000250|UniProtKB:O00139}; kinesin family member 2A; kinesin heavy chain family, member 2; kinesin heavy chain member 2; kinesin heavy chain member 2A; Kinesin, heavy chain, 2; Kinesin-2; Kinesin-like protein KIF2A
基因别名: CDCBM3; HK2; KIF2; KIF2A; KNS2
UniProt ID: (Human) O00139
Entrez Gene ID: (Human) 3796, (Rat) 84391
retrograde vesicle-mediated transport, Golgi to ER
microtubule-based movement
mitotic spindle organization
sister chromatid cohesion
nervous system development
antigen processing and presentation of exogenous peptide antigen via MHC class II
cell differentiation
cell division
mitotic spindle assembly
microtubule depolymerization
metabolic process
