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Invitrogen
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Immunogen sequence: PTFYDFNPHLG MVPPCRLYRA RAGYLTTPHP RAFTSYIKPT SFGPPDLAPG TPPFPYAAFP TPSHPRLQTH
Highest antigen sequence identity to the following orthologs - mouse 82%, rat 82%.
This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin are regulated by a bidirectional promoter.
仅用于科研。不用于诊断过程。未经明确授权不得转售。