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Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7.
Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (87%), Xenopus laevis (90%), Rhesus Monkey (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3.Tissue specificity: Highly expressed in testis and at lower levels in the submandibular salivary gland.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CUL3-interacting protein 1; DKIR homolog; FLJ27152; hDKIR; kelch-like family member 12; Kelch-like protein 12; kelch-like protein C3IP1
基因别名: C3IP1; DKIR; KLHL12
UniProt ID: (Human) Q53G59
Entrez Gene ID: (Human) 59349