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Proteintech
KLKB1 Polyclonal Antibody
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产品信息
27991-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLKB1 Fusion Protein Ag27491 (65-348 aa encoded by NM_000892)
偶联物
形式
Liquid
浓度
0.33 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
The antigen of this antibody just cover the heavy chain of KLKB1, so this antibody cannot recognize the light chain.
Immunogen sequence: MASSINDME KRFGCFLKDS VTGTLPKVHR TGAVSGHSLK QCGHQISACH RDIYKGVDMR GVNFNVSKVS SVEECQKRCT NNIRCQFFSY ATQTFHKAEY RNNCLLKYSP GGTPTAIKVL SNVESGFSLK PCALSEIGCH MNIFQHLAFS DVDVARVLTP DAFVCRTICT YHPNCLFFTF YTNVWKIESQ RNVCLLKTSE SGTPSSSTPQ ENTISGYSLL TCKRTLPEPC HSKIYPGVDF GGEELNVTFV KGVNVCQETC TKMIRCQFFT YSLLPEDCKE EKCKCF (65-348 aa encoded by NM _000892)
靶标信息
Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: antigen, prostate specific; EC 3.4.21.34; Fletcher factor; kallikrein 3, plasma; kallikrein B plasma; kallikrein B, plasma (Fletcher factor) 1; Kininogenin; PKK; Plasma kallikrein; Plasma prekallikrein
基因别名: APS; Kal-3; Kal3; Kalp1; KALP15; KLK3; KLKB1; Pk; PKK; PKKD; PPK; PSA
UniProt ID: (Human) P03952, (Mouse) P26262
Entrez Gene ID: (Human) 3818, (Rat) 25048, (Mouse) 16621
