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Proteintech
KU70/XRCC6 Monoclonal Antibody (3C12D9)
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产品信息
66607-1-IG
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
3C12D9
抗原
KU70,XRCC6 Fusion Protein Ag21301 (307-609 aa encoded by BC008343)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: TGGLLLPSD TKRSQIYGSR QIILEKEETE ELKRFDDPGL MLMGFKPLVL LKKHHYLRPS LFVYPEESLV IGSSTLFSAL LIKCLEKEVA ALCRYTPRRN IPPYFVALVP QEEELDDQKI QVTPPGFQLV FLPFADDKRK MPFTEKIMAT PEQVGKMKAI VEKLRFTYRS DSFENPVLQQ HFRNLEALAL DLMEPEQAVD LTLPKVEAMN KRLGSLVDEF KELVYPPDYN PEGKVTKRKH DNEGSGSKRP KVEYSEEELK THISKGTLGK FTVPMLKEAC RAYGLKSGLK KQELLEALTK HFQD (307-609 aa encoded by B C008343)
靶标信息
XRCC6 is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 5'-dRP/AP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; ATP-dependent DNA helicase II, 70 kDa subunit; CT; CTA-216E10.7; CTC box binding factor 75 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; Ku autoantigen p70 subunit; Ku autoantigen protein p70 homolog; Ku autoantigen, 70kDa; Ku p70; Ku70; Ku70 DNA-binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa); Lupus Ku autoantigen protein p70; OTTHUMP00000028581; thyroid autoantigen; thyroid autoantigen 70 kDa; thyroid autoantigen 70kD (Ku antigen); thyroid autoantigen 70kDa (Ku antigen); Thyroid-lupus autoantigen; thyroid-lupus autoantigen p70; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair cross-complementing protein 6
基因别名: 70kDa; CTC75; CTCBF; G22P1; KU70; Kup70; ML8; TLAA; XRCC6
UniProt ID: (Human) P12956, (Mouse) P23475
Entrez Gene ID: (Human) 2547, (Rat) 25019, (Mouse) 14375
DNA binding
damaged DNA binding
double-stranded DNA binding
double-stranded telomeric DNA binding
ATP-dependent DNA helicase activity
protein binding
ATP binding
protein C-terminus binding
transcription regulatory region DNA binding
poly(A) RNA binding
macromolecular complex binding
5'-deoxyribose-5-phosphate lyase activity
telomeric DNA binding
nucleotide binding
catalytic activity
helicase activity
hydrolase activity
lyase activity
DNA helicase
telomere maintenance
DNA ligation
double-strand break repair via nonhomologous end joining
DNA recombination
transcription, DNA-templated
positive regulation of type I interferon production
DNA duplex unwinding
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of smooth muscle cell proliferation
protein heterotetramerization
cellular response to gamma radiation
cellular response to X-ray
establishment of integrated proviral latency
double-strand break repair via classical nonhomologous end joining
double-strand break repair
cellular response to DNA damage stimulus
brain development
response to ionizing radiation
V(D)J recombination
positive regulation of neurogenesis
cellular hyperosmotic salinity response
DNA repair
regulation of transcription, DNA-templated
metabolic process
