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Invitrogen
Kindlin Polyclonal Antibody
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产品信息
PA1-4360
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide: V(643) H E Y I G G Y I F L S T R S K D Q(660)
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
PA1-4360 detects the URP1 protein in human samples.
PA1-4360 has been successfully used in Western blot procedures.
PA1-4360 immunizing peptide corresponds to amino acid residues 643-660 of the 77 kDa human URP1 protein. The sequence is 100% conserved between mouse, rat, canine, bovine, chimpanzee, and Xenopus.
靶标信息
Kindlin 1 is a member of the kindlin family of focal adhesion proteins and contains a FERM domain and pleckstrin homology domain. It is involved in integrin signaling, linkage of the cytoskeleton to the extracellular matrix, and cell adhesion. It is most often expressed in epithelial cells. When kindlin 1 is coexpressed with talin it helps to activate ITGA2B. It is required for keratinocyte proliferation, polarization of basal keratinocytes in the skin, and for normal cell shape. Mutations in kindlin 1 have been linked to Kindler syndrome, a recessive skin disorder involving blistering, photosensitivity, poikiloderma, and atrophy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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