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In Western blots, reacts with the full length mouse Kininogen (aa 21-661), but not with the light chain alone. In Western blots, no cross-reactivity with recombinant human (rh) Cystatin D, F, SA, SN, recombinant mouse (rm) Cystatin A, B, C, E/M, rmCystatin/Stefin Homolog, rmFetuin A, rhFetuin B, rmHPRG, rhKininogen, or rhKininostatin is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: H-kininigen; Kininogen-1; L-kininogen
基因别名: Kng; Kng1
UniProt ID: (Mouse) O08677
Entrez Gene ID: (Mouse) 16644