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Invitrogen
Kir4.1 (KCNJ10) Polyclonal Antibody
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Kir4.1 (KCNJ10) Antibody (PA5-77822) in ICC/IF
Immunofluorescent analysis of KCNJ10 in human colon carcinoma cell line (RKO). Sample was fixed with 4% formaldehyde (15 min at RT), incubated with KCNJ10 polyclonal antibody (Product # PA5-77822) using a dilution of 1:100 (1 hour at RT), and followed by Goat Anti-Rabbit 488, Phalloidin Texas Red and DAPI secondary antibody at a dilution of 1:100, 1:1000 (60 min at RT) and 1:5000 (5 min at RT). Images are s... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-77822
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide from the mid-protein of Human Kir4.1 (C-QTHQTKEGENIR)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
A 1:1,000 dilution of PA5-77822 was sufficient for detection of Kir4.1 in 15 µg of rat liver cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.|Detects approximately 42 kDa.
靶标信息
The KIR (for inwardly rectifying potassium channel) family of potassium channels possess a greater tendency to allow potassium to flow into the cell rather than out of it. KIR4.1, also known as Kir1.2, is highly expressed in brain including glial cells, astrocytes and cortical neurons. KIR4.1 is also expressed in myelin-synthesizing oligodendrocytes and is crucial to myelination in the developing nervous system. The gene encoding human KIR4.1 maps to chromosome 1. KIR4.2, also known as Kir1.3, is expressed in kidney, lung, heart, thymus and thyroid during development. The gene encoding human KIR4.2 maps to chromosome 21 in the Down syndrome chromosome region 1, and KIR4.2 may play a role in the pathogenesis of Downs syndrome. KIR5.1 forms functional channels only by coexpression with either KIR4.1 or KIR4.2 in the kidney and pancreas.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP-dependent inwardly rectifying potassium channel Kir4.1; ATP-sensitive inward rectifier potassium channel 10; ATP-sensitive inward rectifier potassium channel KAB-2; BIR10; BIRK1; BIRK10; Brain-specific inwardly rectifying K(+) channel 1; Inward rectifier K(+) channel Kir1.2; Inward rectifier K(+) channel Kir4.1; KCNJ13 PEN; kir4.1; Potassium channel, inwardly rectifying subfamily J member 10; potassium inwardly-rectifying channel, subfamily J, member 10
基因别名: Kab-2; KCNJ10
UniProt ID: (Rat) P49655
Entrez Gene ID: (Rat) 29718
potassium ion transport
inflammatory response
visual perception
adult walking behavior
response to blue light
potassium ion import
oligodendrocyte development
optic nerve development
central nervous system myelination
regulation of ion transmembrane transport
regulation of membrane potential
regulation of long-term neuronal synaptic plasticity
protein homotetramerization
response to glucocorticoid
response to mineralocorticoid
regulation of sensory perception of pain
glutamate reuptake
L-glutamate import
potassium ion homeostasis
regulation of resting membrane potential
membrane hyperpolarization
potassium ion transmembrane transport
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