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NeoBiotechnologies
Ku (p70/p80) (Nuclear Marker) Monoclonal Antibody (KU729), PE
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
2547-MSM1-PE-100T
产品规格
种属反应
Human,
Non-human primate
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
KU729
抗原
Nuclear extract of human HL-60 cells
偶联物
PE
PE
PE
激发/发射光谱
565/576 nm
查看光谱
形式
Liquid
浓度
100 µg/mL
规格
50 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Does not react with Mouse, Rat or Chicken
靶标信息
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008].
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; ATP-dependent DNA helicase II, 70 kDa subunit; CTC box binding factor 75 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; DNA repair protein XRCC6; G22P1; Ku (p70/p80) subunit; Ku antigen; Ku autoantigen p70 subunit; Ku autoantigen, 70kDa; Ku autoantigen, 80kDa; Ku protein subunit; Ku86 autoantigen related protein 1; lupus Ku autoantigen protein p70; lupus Ku autoantigen protein p86; nuclear factor IV; p70 autoantigen; thyroid autoantigen; thyroid autoantigen 70kD (Ku antigen); thyroid autoantigen 70kDa (Ku antigen); thyroid-lupus autoantigen; thyroid-lupus autoantigen p70; TLAA; unnamed protein product; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); X-ray repair complementing defective repair in Chinese hamster cells 6
基因别名: CTC75; CTCBF; G22P1; KARP-1; KARP1; KU70; KU80; Ku86; KUB2; ML8; NFIV; TLAA
UniProt ID: (Human) P13010, (Human) P12956
Entrez Gene ID: (Human) 7520, (Human) 2547
transcription regulatory region sequence-specific DNA binding
DNA binding
DNA helicase activity
damaged DNA binding
double-stranded DNA binding
double-stranded telomeric DNA binding
RNA binding
protein binding
enzyme activator activity
DNA-dependent ATPase activity
ATPase activity
ubiquitin protein ligase binding
U3 snoRNA binding
telomeric DNA binding
3'-5' DNA helicase activity
macromolecular complex binding
DNA end binding
5'-deoxyribose-5-phosphate lyase activity
class I DNA-(apurinic or apyrimidinic site) endonuclease activity
cyclin binding
scaffold protein binding
telomere maintenance
recombinational repair
activation of innate immune response
immune system process
positive regulation of immune system process
double-strand break repair via nonhomologous end joining
response to ionizing radiation
positive regulation of lymphocyte differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of smooth muscle cell proliferation
cellular hyperosmotic salinity response
cellular response to gamma radiation
cellular response to X-ray
double-strand break repair via classical nonhomologous end joining
double-strand break repair
DNA recombination
cellular response to DNA damage stimulus
telomere maintenance via telomerase
regulation of telomere maintenance
small-subunit processome assembly
protein localization to chromosome, telomeric region
negative regulation of t-circle formation
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