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Recommended positive controls: 293T.
Predicted reactivity: Mouse (97%), Rat (96%), Zebrafish (86%), Xenopus laevis (87%), Chicken (98%), Rhesus Monkey (100%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3; MAPK scaffold protein 1; MEK binding partner 1; MEK partner 1; MEK-binding partner 1; mitogen activated protein, binding protein; mitogen-activated protein kinase kinase 1 interacting protein 1; Mitogen-activated protein kinase kinase 1-interacting protein 1; Mitogen-activated protein kinase scaffold protein 1; Mp1; Ragulator complex protein LAMTOR3
基因别名: AW556229; LAMTOR3; MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633; PRO2783; Ragulator3
UniProt ID: (Human) Q9H364, (Rat) Q5U204, (Mouse) O88653
Entrez Gene ID: (Human) 8649, (Rat) 362045, (Mouse) 56692