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Invitrogen
LAX1 Polyclonal Antibody
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产品信息
PA5-52012
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.6 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: PWRQEDLGRH ESRSMRIFST ESLLSRNSES PEHVPSQAGN AFQEHTAHIH ATEYAVGIYD NAMVPQMCGN LTPSAHCINV RASRDCASIS SEDSHDYVNV PTAEEIAETL ASTKSPSRNL FVLPSTQKLE FTEERDEGCG DAGDC
Highest antigen sequence identity to the following orthologs: Mouse - 50%, Rat - 52%.
靶标信息
Lymphocyte activation gene 1 (LAX1) is located on chromosome 2p16.1 and encodes an immunoregulatory protein that is expressed primarily on lymphocytes, including T cells, B cells, and other immune cells. LAX1 functions as a negative regulator of lymphocyte activation and signaling, playing a crucial role in maintaining immune homeostasis by attenuating excessive immune responses. It acts by modulating signaling pathways that are initiated through surface receptors on lymphocytes, thereby influencing lymphocyte proliferation, cytokine production, and cellular responses during immune activation. Dysregulation of LAX1 expression or function can lead to autoimmune diseases due to impaired control of immune activation. Research into LAX1 focuses on its potential for therapeutic modulation in autoimmune disorders and its role in balancing immune responses, which is essential for maintaining health and preventing pathogenic immune conditions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: LAT-like membrane associated protein; Linker for activation of X cells; Lymphocyte transmembrane adapter 1; Membrane-associated adapter protein LAX
基因别名: LAX; LAX1
UniProt ID: (Human) Q8IWV1
Entrez Gene ID: (Human) 54900
