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Invitrogen
LEFTY Polyclonal Antibody
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LEFTY Antibody (PA5-19507) in WB
Western blot analysis of Recombinant Mouse Lefty-1 Protein using Product # PA5-19507, Lefty primary antibody at a dilution of 1 µg/mL (lane 1). Staining of Recombinant Human Lefty-1 Protein at a dilution of 1 µg/mL (lane 2). Blot treated with a secondary IR Dye680-conjugated Goat polyclonal anti-Rabbit antibody was used at a dilution of 1:10000.
产品信息
PA5-19507
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide conjugated to KLH derived from within residues 350 to the C-terminus of Human Lefty.
偶联物
形式
Liquid
浓度
1.0 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA5-19507 targets Lefty in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples.
The PA5-19507 immunogen is synthetic peptide conjugated to KLH derived from within residues 350 to the C-terminus of Human Lefty.
PA5-19507 detects Lefty which has a predicted molecular weight of approximately 44 kDa.
靶标信息
This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Left-right determination factor 1; Left-right determination factor B; left-right determination, factor B; Lefty protein; Protein lefty-1; Protein lefty-B; Stimulated by retinoic acid gene 3 protein; TGF-beta-4; Transforming growth factor beta-4
基因别名: AI450052; Ebaf; LEFTB; Lefty; lefty-1; LEFTY1; LEFTYB; Stra3; Tgfb4; UNQ278/PRO317
UniProt ID: (Human) O75610, (Mouse) Q64280
Entrez Gene ID: (Human) 10637, (Mouse) 13590
negative regulation of transcription from RNA polymerase II promoter
heart morphogenesis
transforming growth factor beta receptor signaling pathway
determination of left/right symmetry
positive regulation of pathway-restricted SMAD protein phosphorylation
cell growth
regulation of apoptotic process
regulation of MAPK cascade
cell development
SMAD protein signal transduction
multicellular organism development
negative regulation of cell proliferation
anterior/posterior axis specification
response to retinoic acid
growth
cell migration involved in gastrulation
negative regulation of nodal signaling pathway
negative regulation of nodal receptor complex assembly
