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Proteintech
LEFTY2 Polyclonal Antibody
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产品信息
13991-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
LEFTY2 Fusion Protein Ag5073 (24-366 aa encoded by BC035718)
偶联物
形式
Liquid
浓度
0.38 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: EEQLLGSLL RQLQLSEVPV LDRADMEKLV IPAHVRAQYV VLLRRSHGDR SRGKRFSQSF REVAGRFLAS EASTHLLVFG MEQRLPPNSE LVQAVLRLFQ EPVPKAALHR HGRLSPRSAQ ARVTVEWLRV RDDGSNRTSL IDSRLVSVHE SGWKAFDVTE AVNFWQQLSR PRQPLLLQVS VQREHLGPLA SGAHKLVRFA SQGAPAGLGE PQLELHTLDL RDYGAQGDCD PEAPMTEGTR CCRQEMYIDL QGMKWAKNWV LEPPGFLAYE CVGTCQQPPE ALAFNWPFLG PRQCIASETA SLPMIVSIKE GGRTRPQVVS LPNMRVQKCS CASDGALVPR RLQP (24-366 aa encoded by BC035718)
靶标信息
Left-right determination factor 1 and 2 (Lefty1/2) belong to the TGF-beta superfamily of proteins and are responsible for determination of left-right positioning of visceral organs during embryogenesis. Lefty1 acts as a regulator of Lefty2 and NODAL as the lack of the former resulted in bilateral expression of nodal, lefty2 and Pitx2 (a homeobox gene normally expressed on the left side and blocks the signal for leftness). Lefty2 may play a role in endometrial bleeding.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: endometrial bleeding associated factor; Endometrial bleeding-associated factor; Left-right determination factor 2; Left-right determination factor A; Left-right determination factor B; left-right determination, factor A; MGC46222; Protein lefty-2; Protein lefty-A; Protein lefty-B; TGF-beta-4; Transforming growth factor beta-4
基因别名: 6030463A22Rik; AV214969; EBAF; Ebaf2; LEFTA; Leftb; LEFTY2; LEFTYA; PSEC0024; TGFB4
UniProt ID: (Human) O00292, (Mouse) P57785
Entrez Gene ID: (Human) 7044, (Rat) 289316, (Mouse) 320202
platelet degranulation
transforming growth factor beta receptor signaling pathway
multicellular organism development
positive regulation of pathway-restricted SMAD protein phosphorylation
cell growth
regulation of apoptotic process
regulation of MAPK cascade
cell development
SMAD protein signal transduction
negative regulation of transcription from RNA polymerase II promoter
heart morphogenesis
determination of left/right symmetry
biological_process
negative regulation of cell proliferation
anterior/posterior axis specification
response to retinoic acid
cell migration involved in gastrulation
negative regulation of nodal receptor complex assembly
growth
