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Proteintech
LGP2 Polyclonal Antibody
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产品信息
11355-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse,
Non-human primate,
Pig
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
LGP2 Fusion Protein Ag1910 (330-678 aa encoded by BC014949)
偶联物
形式
Liquid
浓度
0.17 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: LFDDRKNEL AHLATHGPEN PKLEMLEKIL QRQFSSSNSP RGIIFTRTRQ SAHSLLLWLQ QQQGLQTVDI RAQLLIGAGN SSQSTHMTQR DQQEVIQKFQ DGTLNLLVAT SVAEEGLDIP HCNVVVRYGL LTNEISMVQA RGRARADQSV YAFVATEGSR ELKRELINEA LETLMEQAVA AVQKMDQAEY QAKIRDLQQA ALTKRAAQAA QRENQRQQFP VEHVQLLCIN CMVAVGHGSD LRKVEGTHHV NVNPNFSNYY NVSRDPVVIN KVFKDWKPGG VISCRNCGEV WGLQMIYKSV KLPVLKVRSM LLETPQGRIQ AKKWSRVPFS VPDFDFLQHC AENLSDLSLD (330-678 aa encoded by BC014949)
靶标信息
Anti-viral innate immune responses are triggered by pathogen-associated molecular patters (such as the accumulation of intracellular nucleic acids resulting from virus infections) and represent the first line of defense against numerous infectious organisms. The Toll-like receptors (TLR) 3, 7, 8, and 9 are expressed in immune cells and function as transmembrane pattern recognition receptors to detect foreign nucleic acids. Other proteins that play similar roles, such as RIG-1 and MDA5 are members of a CARD-helicase family and are expressed in the cytoplasm. A third protein, LGP2, is similar to RIG-1 and MDA5, except for lacking a homologous CARD domain. It is thought to act as an element of negative-feedback regulation of intracellular antiviral signaling. At least four isoforms of LGP2 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ATP-dependent helicase LGP2; ATP-dependent RNA helicase DHX58; DEXH (Asp-Glu-X-His) box polypeptide 58; ortholog of mouse D11lgp2; probable ATP-dependent helicase LGP2; probable ATP-dependent RNA helicase DHX58; Protein D11Lgp2; Protein D11Lgp2 homolog; RIG-I-like receptor 3; RIG-I-like receptor LGP2; RLR; RLR-3; RNA helicase LGP2
基因别名: B430001I08Rik; D11LGP2; D11LGP2E; DHX58; LGP2; LPG2; RGD1310093; RLR-3
UniProt ID: (Human) Q96C10, (Mouse) Q99J87
Entrez Gene ID: (Human) 79132, (Mouse) 80861, (Rat) 303538
response to virus
negative regulation of type I interferon production
positive regulation of type I interferon production
negative regulation of MDA-5 signaling pathway
negative regulation of RIG-I signaling pathway
innate immune response
regulation of innate immune response
negative regulation of innate immune response
defense response to virus
positive regulation of MDA-5 signaling pathway
positive regulation of RIG-I signaling pathway
immune system process
metabolic process
