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Invitrogen
LILRC2 Polyclonal Antibody
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产品信息
PA5-148820
产品规格
种属反应
Rat
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant rat LILRC2, Gly24-Asn230
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
LILRC2, also known as Leukocyte Immunoglobulin-Like Receptor Subfamily C Member 2 (LILRC2), is a gene that encodes a member of the leukocyte immunoglobulin-like receptor (LILR) family. These receptors are primarily expressed on the surface of various immune cells, including B cells, dendritic cells, monocytes, and natural killer (NK) cells. LILRC2 functions as an inhibitory receptor, playing a critical role in the modulation of immune responses. By binding to specific ligands, such as major histocompatibility complex (MHC) class I molecules, LILRC2 can transmit inhibitory signals that dampen immune cell activation, thereby maintaining immune homeostasis and preventing excessive or inappropriate immune responses. This regulatory function is crucial for preventing autoimmunity and maintaining tolerance to self-antigens. Dysregulation or altered expression of LILRC2 has been associated with various immune-related conditions, including autoimmune diseases, chronic infections, and cancers. Understanding the specific roles and signaling mechanisms of LILRC2 is important for developing therapeutic strategies aimed at modulating immune responses, enhancing immune tolerance, and treating immune-mediated diseases. Research into LILRC2 provides valuable insights into the intricate balance of immune regulation and the potential for targeting inhibitory receptors in immunotherapy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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