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Proteintech
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Immunogen sequence: MRFAWTVLL LGPLQLCALV HCAPPAAGQQ QPPREPPAAP GAWRQQIQWE NNGQVFSLLS LGSQYQPQRR RDPGAAVPGA ANASAQQPRT PILLIRDNRT AAARTRTAGS SGVTAGRPRP TARHWFQAGY STSRAREAGA SRAENQTAPG EVPALSNLRP PSRVDGMVGD DPYNPYKYSD DNPYYNYYDT YERPRPGGRY RPGYGTGYFQ YGLPDLVADP YYIQASTYVQ KMSMYNLRCA AEENCLASTA YRADVRDYDH RVLLRFPQRV KNQGTSDFLP SRPRYSWEWH SCHQHYHSMD EFSHYDLLDA NTQRRVAEGH KASFCLEDTS CDYGYHRRFA CTAHTQGLSP GCYDTYGADI DCQWIDITDV KPGNYILKVS VNPSYLVPES DYTNNVVRCD IRYTGHHAYA SGCTISPY (1-417 aa encoded by BC074872)
Lysyl oxidase (LOX), a copper-containing amine oxidase, belongs to a heterogeneous family of enzymes that oxidize primary amine substrates to reactive aldehydes. It plays a vital role in the formation and repair of the extra cellular matrix. As well, LOX is a multifunctional enzyme having diverse biological functions such as developmental regulation, tumor suppression, cell motility and cellular senescence. The secreted form of LOX is responsible for the invasive properties of hypoxic human cancer cells. Thus, it is essential for hypoxia-induced metastasis and is a good therapeutic target for preventing and treating metastases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Lysyl oxidase; MGC105112; Protein-lysine 6-oxidase; Ras excision protein; ras recision
基因别名: AI893619; LOX; Rrg; TSC-160
UniProt ID: (Human) P28300, (Mouse) P28301
Entrez Gene ID: (Human) 4015, (Mouse) 16948