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Abnova
LXN Polyclonal Antibody, MaxPab™
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Product Details
H00056925-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LXN (NP_064554.2, 1 a.a. approximately 222 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MEIPPTNYPA SRAALVAQNY INYQQGTPHR VFEVQKVKQA SMEDIPGRGH KYRLKFAVEE IIQKQVKVNC TAEVLYPSTG QETAPEVNFT FEGETGKNPD EEDNTFYQRL KSMKEPLEAQ NIPDNFGNVS PEMTLVLHLA WVACGYIIWQ NSTEDTWYKM VKIQTVKQVQ RNDDFIELDY TILLHNIASQ EIIPWQMQVL WHPQYGTKVK HNSRLPKEVQ LE
Target Information
Latexin, also known as LXN, is a carboxypeptidase A inhibitor found in mammals, and it shares structural similarities with cystatin C, suggesting its role in protein abundance regulation. The LXN gene is located on chromosome 3, specifically at 3q25.32, encompassing 5 exons and coding for a protein of 222 amino acids. Latexin is identified as a molecular marker in the developing rat brain and is known for its tumor suppressive activities. With a molecular weight of 29 kDa, LXN is highly expressed in macrophages and plays a significant role in the inflammatory immune response, including regulating macrophage polarity and enhancing tumor immune surveillance. Research involving a Lxn knockout mouse model has demonstrated its importance in the regulation of hematopoietic stem cell function, suggesting its involvement in cellular homeostasis and survival mechanisms. Additionally, latexin contributes to sex dimorphism in hematopoiesis through gender-specific differential expression of microRNA, indicating its nuanced role in genetic regulation and cellular processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ECI; Endogenous carboxypeptidase inhibitor; Latexin; latexin protein; MUM; Protein MUM; TCI; Tissue carboxypeptidase inhibitor
Gene Aliases: ECI; LXN; TCI
UniProt ID: (Human) Q9BS40
Entrez Gene ID: (Human) 56925
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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