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LYN Monoclonal Antibody (3C7F2)

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LYN Monoclonal Antibody (3C7F2)

产品信息

60211-1-IG

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
查看2篇已发表文章 2篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

3C7F2

抗原

LYN Fusion Protein Ag12723 (132-512 aa encoded by BC075002)
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.08 mg/mL

规格

162 µg

纯化类型

Protein A

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: KDITRKDAE RQLLAPGNSA GAFLIRESET LKGSFSLSVR DFDPVHGDVI KHYKIRSLDN GGYYISPRIT FPCISDMIKH YQKQADGLCR RLEKACISPK PQKPWDKDAW EIPRESIKLV KRLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSVQAFLEE ANLMKTLQHD KLVRLYAVVT REEPIYIITE YMAKGSLLDF LKSDEGGKVL LPKLIDFSAQ IAEGMAYIER KNYIHRDLRA ANVLVSESLM CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINFGCF TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA DVMTALSQGY RMPRVENCPD ELYDIMKMCW KEKAEERPTF DYLQSVLDDF YTATEGQYQQ QP (132-512 aa encoded by BC075002)

靶标信息

Lyn proto oncogene (Lcl/Yes related novel protein tyrosine kinase) is encoded by the Lyn gene located on chromosome 8 in humans and belongs to the Src family kinase. It is a non-receptor tyrosine kinase that acts as a mediator in transducing cellular signaling. The most well studied expression of Lyn is in hematopoietic cell types, both lymphoid and myeloid cells with exclusion in T lymphocytes. It has also been observed that Lyn plays diverse roles such as in regulation of B cell receptor signaling, mast cell signaling and Epithelial - Mesenchymal Transition (EMT).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: FLJ26625; lck/Yes-related novel protein tyrosine kinase; lyn; lyn tyrosine kinase; protein-tyrosine kinase (EC 2.7.1.112); unnamed protein product; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Yamaguchi sarcoma viral (v-yes-1) oncogene homolog

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基因别名: Hck-2; JTK8; p53Lyn; p56Lyn; SAIDV

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UniProt ID: (Human) P07948, (Mouse) P25911

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Entrez Gene ID: (Human) 4067, (Mouse) 17096

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功能
protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding platelet-derived growth factor receptor binding integrin binding protein binding ATP binding kinase activity enzyme binding receptor activator activity ubiquitin protein ligase binding immunoglobulin receptor binding gamma-tubulin binding glycosphingolipid binding ion channel binding macromolecular complex binding ephrin receptor binding phosphoprotein binding scaffold protein binding phosphorylation-dependent protein binding erythropoietin receptor binding SH3 domain binding phosphatidylinositol 3-kinase activator activity
参与通路
DNA damage checkpoint cell morphogenesis B cell homeostasis regulation of cytokine production negative regulation of protein phosphorylation hematopoietic progenitor cell differentiation Fc receptor mediated stimulatory signaling pathway tolerance induction to self antigen histamine secretion by mast cell platelet degranulation negative regulation of myeloid leukocyte differentiation immune response-regulating cell surface receptor signaling pathway Fc receptor mediated inhibitory signaling pathway regulation of B cell apoptotic process protein phosphorylation autophagy defense response inflammatory response cellular response to DNA damage stimulus transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell proliferation negative regulation of cell proliferation response to hormone positive regulation of neuron projection development fatty acid transport vesicle-mediated transport peptidyl-tyrosine phosphorylation hemopoiesis erythrocyte differentiation eosinophil differentiation positive regulation of cell migration negative regulation of B cell proliferation neuron projection development lipopolysaccharide-mediated signaling pathway regulation of mast cell activation regulation of cell adhesion mediated by integrin negative regulation of toll-like receptor 2 signaling pathway toll-like receptor 4 signaling pathway negative regulation of toll-like receptor 4 signaling pathway positive regulation of toll-like receptor 4 signaling pathway positive regulation of toll-like receptor 9 signaling pathway intracellular signal transduction interleukin-5-mediated signaling pathway C-X-C chemokine receptor CXCR4 signaling pathway B cell proliferation positive regulation of phosphorylation hemoglobin biosynthetic process regulation of mast cell degranulation negative regulation of MAP kinase activity positive regulation of MAPK cascade regulation of erythrocyte differentiation protein autophosphorylation ephrin receptor signaling pathway regulation of inflammatory response B cell receptor signaling pathway regulation of B cell receptor signaling pathway negative regulation of B cell receptor signaling pathway regulation of release of sequestered calcium ion into cytosol positive regulation of glial cell proliferation positive regulation of Fc receptor mediated stimulatory signaling pathway regulation of ERK1 and ERK2 cascade negative regulation of ERK1 and ERK2 cascade positive regulation of oligodendrocyte progenitor proliferation negative regulation of mast cell proliferation positive regulation of mast cell proliferation cellular response to retinoic acid regulation of monocyte chemotaxis regulation of platelet aggregation dendritic cell differentiation neuroinflammatory response negative regulation of intracellular signal transduction positive regulation of amyloid precursor protein catabolic process positive regulation of protein localization to plasma membrane positive regulation of dendritic cell apoptotic process regulation of protein phosphorylation stimulatory C-type lectin receptor signaling pathway innate immune response-activating signal transduction negative regulation of inflammatory response to antigenic stimulus response to sterol depletion signal transduction response to xenobiotic stimulus response to toxic substance response to carbohydrate oligodendrocyte development T cell costimulation response to insulin cellular response to heat Fc-epsilon receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis response to amino acid response to peptide hormone response to axon injury negative regulation of immune response leukocyte migration JAK-STAT cascade involved in growth hormone signaling pathway cellular response to lipid
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