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Invitrogen
LZTR2 Polyclonal Antibody
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FIGURE: 1 / 1
LZTR2 Antibody (PA5-89978) in WB
Western blot analysis of LZTR2 in extracts of various cell lines. Samples were incubated with LZTR2 Polyclonal antibody (Product # PA5-89978) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
Product Details
PA5-89978
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 250-550 of human SEC16B (NP_1491182)
Conjugate
Form
Liquid
Concentration
1.75 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DPPASAAWSP VQADVSSAGP KAPMKFYIPH VPVSFGPGGQ LVHVGPSSPT DGQAALVELH SMEVILNDSE EQEEMRSFSG PLIREDVHKV DIMTFCQQKA AQSCKSETLG SRDSALLWQL LVLLCRQNGS MVGSDIAELL MQDCKKLEKY KRQPPVANLI NLTDEDWPVL SSGTPNLLTG EIPPSVETPA QIVEKFTRLL YYGRKKEALE WAMKNHLWGH ALFLSSKMDP QTYSWVMSGF TSTLALNDPL QTLFQLMSGR IPQAATCCGE KQWGDWRPHL AVILSNQAGD PELYQRAIVA I; Positive Samples: HeLa, Mouse pancreas; Cellular Location: Endoplasmic reticulum membrane, Golgi apparatus membrane, Peripheral membrane protein
Target Information
LZTR2, also known as RGPR-p117, is a member of the BTB-kelch superfamily and was initially described as a nuclear factor I (NFI) binding protein and transcriptional regulator of the regucalcin gene. LZTR2 is cytoplasmically localized but is thought to translocate to the nucleus, a process mediated by protein kinase C signaling following hormonal stimulation. Recent evidence has suggested that there is a strong correlation of single nucleotide polymorphisms of LZTR2 with obesity in the Japanese population similar to that seen with the TMEM18 gene and the GNPDA2, BDNF, FAIM2, and MC4R genes with obesity in Caucasian populations, suggesting LZTR2 may play a role in metabolism and obesity risk.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Leucine zipper transcription regulator 2; protein SEC16 homolog B; Protein transport protein Sec16B; Regucalcin gene promoter region-related protein p117; regucalcin gene promotor region related protein; RGPR-p117; SEC16 homolog B
Gene Aliases: KIAA1928; LZTR2; PGPR-p117; RGPR; Rgpr-p117; SEC16B; SEC16S
UniProt ID: (Human) Q96JE7, (Mouse) Q91XT4
Entrez Gene ID: (Human) 89866, (Mouse) 89867
transport
endoplasmic reticulum organization
peroxisome organization
positive regulation of gene expression
protein transport
vesicle-mediated transport
peroxisome fission
COPII vesicle coating
positive regulation of protein exit from endoplasmic reticulum
protein localization to endoplasmic reticulum
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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