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Invitrogen
LZTS2 Polyclonal Antibody
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LZTS2 Antibody (PA5-89929) in WB
Western blot analysis of LZTS2 in extracts of various cell lines. Samples were incubated with LZTS2 Polyclonal antibody (Product # PA5-89929) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
产品信息
PA5-89929
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 470-669 of human LZTS2 (NP_1158051)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: ELVALRVALR EARATLRVSE GRARGLQEAA RARELELEAC SQELQRHRQE AEQLREKAGQ LDAEAAGLRE PPVPPATADP FLLAESDEAK VQRAAAGVGG SLRAQVERLR VELQRERRRG EEQRDSFEGE RLAWQAEKEQ VIRYQKQLQH NYIQMYRRNR QLEQELQQLS LELEARELAD LGLAEQAPCI CLEEITATEI; Positive Samples: DU145, HT-29, HeLa, U-87MG, MCF7, Mouse brain, Rat kidney, Rat brain; Cellular Location: Cytoplasm, centrosome, cytoskeleton, microtubule organizing center
靶标信息
LZTS2 is a negative regulator of katanin-mediated microtubule severing and release from the centrosome. LZTS2 is required for central spindle formation and the completion of cytokinesis.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hLZTS2; Leucine zipper putative tumor suppressor 2; leucine zipper putative tumor suppressor 2 {ECO:0000255|HAMAP-Rule:MF_03026}; leucine zipper, putative tumor suppressor 2; Protein LAPSER1; putative tumor suppressor LAPSER1; RP11-108L7.8
基因别名: BC014695; KIAA1813; LAPSER1; LZTS2; mKIAA1813
UniProt ID: (Human) Q9BRK4, (Mouse) Q91YU6, (Rat) Q3LUD4
Entrez Gene ID: (Human) 84445, (Mouse) 226154, (Rat) 365468
cytokinesis
kidney development
mitotic nuclear division
negative regulation of cell proliferation
positive regulation of cell death
Wnt signaling pathway
microtubule severing
nuclear export
spindle midzone assembly
negative regulation of canonical Wnt signaling pathway
negative regulation of protein localization to nucleus
cell cycle
negative regulation of Wnt signaling pathway
cell division
renal system development
