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Recognizes the lamina, i.e. the nucleoplasmic layer coating the nuclear envelope.
Lamins are a class of intermediate filament proteins that form a matrix on the inner surface of the nuclear envelope. These proteins are found in many different cell types in three different forms (A, B, and C). Lamins A and C are alternatively spliced versions of the LMNA gene. The LMNA gene has been linked to many disorders of the muscular system, nervous system, and the fat distributions systems including: Emery-Dreifuss muscular dystrophy, Dunnigan-type familial partial lipodystrophy (FPLD), limb-girdle muscular dystrophy (LGMD1B), dilated cardiomyopathy (CMD1A), axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1), and mandibuloacral dysplasia (MAD).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 70 kDa lamin; Lamin A+C mutant; lamin a-c; lamin A/C-like 1; Lamin AC; lamin C; Lamin-A; lamin-A/C; mutant 453W; Mutant lamin A/C; nuclear intermediate filament protein; Prelamin-A/C; progerin mutant; renal carcinoma antigen NY-REN-32; RP11-54H19.1; unnamed protein product
基因别名: cb948; CDCD1; CDDC; CMD1A; CMT2B1; Dhe; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNA; lmna-A; LMNC; LMNL1; PRO1; wu:fk66d12; XELAEV_18040808mg
UniProt ID: (Human) P02545, (Mouse) P48678, (Xenopus) P11048
Entrez Gene ID: (Bovine) 404144, (Human) 4000, (Mouse) 16905, (Zebrafish) 195815, (Xenopus) 373673