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Invitrogen
Laminin Polyclonal Antibody
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产品信息
PA1-36119
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
EHS-mouse sarcoma.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存条件
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
运输条件
Wet ice
RRID
产品详细信息
This antibody can be used to detect laminin proteins in immunohistochemistry using frozen sections or standard formaldehyde-fixed paraffin-embedded tissues. For IHC (F), fixation with acetone for 5 min. at -20°C is recommended. For IHC (P), proteolytic treatment with pepsin is recommended. Before use, dilute immediately using PBS or Tris. Recommended positive control: skin or kidney tissue.
Store undiluted antibody at 2-8°C for 2 months. For long-term storage, aliquote and store at -20°C, avoiding freeze/thaw cycles.
靶标信息
Laminin is a crucial glycoprotein that plays a significant role in the extracellular matrix, particularly within the basement membrane. It is composed of three subunits: alpha, beta, and gamma chains. These chains are disulfide-linked polypeptides that together form a heterotrimer, resembling the shape of a cross. The human genome encodes 11 genetically distinct laminin chains, which combine to form over 14 different laminin isoforms, each with specific tissue distributions and functions. Laminins can bind to other laminin molecules, as well as integrins and other matrix proteins, providing structural support and influencing cell differentiation, migration, and adhesion. These glycoproteins are vital during early embryonic development, where they contribute to the formation of basement membrane-like structures, even in the absence of type IV collagen. The evolutionary origin of laminin gene families can be traced back to early branching animals, providing insights into metazoan gene family development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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