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Invitrogen
Lendalizumab Humanized Recombinant Human Monoclonal Antibody
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产品信息
MA5-59283
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG2SA
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
靶标信息
Lendalizumab, also known as an anti-C5 antibody, is a human monoclonal antibody targeting complement component 5 (C5). Complement component 5 (C5) is a vital protein in the complement system, part of the innate immune response. It is coded by the C5 gene located on chromosome 9, and consists of alpha and beta polypeptide chains. Activation of C5 occurs through the cleavage by C5 convertases in the classical, lectin, or alternative pathways, resulting in two fragments, C5a and C5b. C5a acts as an anaphylatoxin, promoting inflammation by stimulating chemotaxis and activating various immune cells. C5b initiates assembly of the membrane attack complex (MAC), leading to cell lysis. Dysregulation of C5 has been associated with autoimmune diseases such as myasthenia gravis and collagen-induced arthritis. Recent studies have explored the use of siRNA targeting C5 to mitigate disease symptoms by inhibiting C5 activation and subsequent inflammatory responses.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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