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Invitrogen
Lewis Y Humanized Biosimilar Recombinant Human Monoclonal Antibody
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产品信息
MA5-58691
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
This antibody can also be cross referenced by the term MB 311.
靶标信息
The Lewis Y (Le^y) gene is not actually a single gene but refers to a carbohydrate antigen known as Lewis Y or Le^y antigen, which is part of the Lewis blood group system. This antigen is synthesized by the fucosylation of precursor substances, which involves enzymes encoded by the FUT1 (fucosyltransferase 1) and FUT2 genes. These genes are responsible for the addition of fucose, a hexose deoxy sugar, to the precursor oligosaccharides. The expression of Lewis Y antigen has been extensively studied in the context of cancer biology as it is commonly found on the surface of epithelial and endothelial cells but overexpressed in various types of cancers, including colorectal, gastric, and ovarian carcinomas. The overexpression and altered glycosylation patterns of Le^y antigen in tumors have made it a potential biomarker for cancer diagnosis and a target for immunotherapeutic approaches.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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