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Invitrogen
LexA Polyclonal Antibody
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产品信息
PA1-4967
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Full size LexA protein.
偶联物
形式
Liquid
保存条件
4°C or -80°C if preferred
运输条件
Wet ice
RRID
产品详细信息
PA1-4967 detects LexA protein in E.coli and yeast samples.
PA1-49667 has been successfully used in Western blot, immunohistochemistry, and immunoprecipitation proceedures. It is specific for the ~23 kDa LexA protein.
PA1-4967 immunogen is a highly purified recombinant full size 23 kDa LexA protein.
靶标信息
E. coli LexA protein inhibits the transcription of the genes belonging to the SOS regulon that are related to DNA repair and cell division by recognizing and binding to the SOS-box sequence. LexA‘s self-protease activity is promoted by RecA protein which, responding to DNA damage, is activated by its binding to single-strand DNA accumulated in the cells. It is cleaved into two fragments and loses its function as a repressor. As the result, the expression of genes belonging to the SOS regulon is induced, and mutagenic activity in the cells are enhanced.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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