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Invitrogen
Livin Polyclonal Antibody
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产品信息
PA5-94927
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human Livin recombinant protein (Position: E87-S298).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Human Livin shares 69.8% amino acid (aa) sequence identity with mouse Livin.
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: HELA whole cell, A431 whole cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity. Recently, it has been identified that a novel human inhibitor of apoptosis protein (IAP) family member termed Livin or ML-IAP, which contains a single baculoviral IAP repeat (BIR) domain and a COOH-terminal RING finger domain. Livin gene has two splicing variants that contain open reading frames of 298 and 280 amino acids and both contained a single copy of baculovirus IAP repeat (BIR) and RING domain. Both of the isoforms inhibit TNFa induced apoptosis in Jurkat cells. Livin expression is low in adult tissues. It is relatively expressed at a higher level in developmental tissues and in many cancer cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Baculoviral IAP repeat-containing protein 7; KIAP; Kidney inhibitor of apoptosis protein; Livin; livin inhibitor of apoptosis; Melanoma inhibitor of apoptosis protein; ML-IAP; RING finger protein 50; RING-type E3 ubiquitin transferase BIRC7; RP11-261N11.7
基因别名: BIRC7; KIAP; LIVIN; ML-IAP; MLIAP; RNF50; UNQ5800/PRO19607/PRO21344
UniProt ID: (Human) Q96CA5
Entrez Gene ID: (Human) 79444
apoptotic process
activation of JUN kinase activity
regulation of signal transduction
protein ubiquitination
regulation of cell proliferation
negative regulation of apoptotic process
regulation of natural killer cell apoptotic process
mitotic spindle assembly
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
