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Abnova
MAGI2 Monoclonal Antibody (6C8)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00009863-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
6C8
抗原
MAGI2 (NP_036433, 519 a.a. approximately 628 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: PANSMVPPLA IMERPPPVMV NGRHNYETYL EYISRTSQSV PDITDRPPHS LHSMPTDGQL DGTYPPPVHD DNVSMASSGA TQAELMTLTI VKGAQGFGFT IADSPTGQRV
靶标信息
Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. Florindo C.S., Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. The MGC Project Team, Genome Res. 14:2121-2127(2004). Devroe E., J. Biol. Chem. 279:24444-24451(2004).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: activin receptor interacting protein 1; atrophin-1-interacting protein 1; atrophin-1-interacting protein A; MAGUK-like protein with 5 PDZ domains, 2 WW domains and a guanylate kinase-like domain; membrane-associated guanylate kinase inverted 2; unnamed protein product
基因别名: ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2; NPHS15; SSCAM
UniProt ID: (Human) Q86UL8
Entrez Gene ID: (Human) 9863
positive regulation of receptor internalization
signal transduction
negative regulation of cell proliferation
positive regulation of neuron projection development
negative regulation of cell migration
negative regulation of activin receptor signaling pathway
nerve growth factor signaling pathway
receptor clustering
negative regulation of protein kinase B signaling
Wnt signaling pathway, planar cell polarity pathway
SMAD protein signal transduction
glomerular visceral epithelial cell development
clathrin-mediated endocytosis
cellular response to nerve growth factor stimulus
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
