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Invitrogen
MAP1 Polyclonal Antibody
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产品信息
PA5-51487
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human MAP1
偶联物
形式
Liquid
浓度
0.1 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Immunogen sequence: RRRLLESLRG PALDVIRVLK INNPLITVDE CLQALEEVFG VTDNPRELQV KYLTTYQKDE EKLSAYVLRL EPLLQKLVQR GAIERDAVNQ ARLDQVIAGA VHKTIRRELN LPEDGPAPGF LQLLVLIKDY EAAE
Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 78%.
靶标信息
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A related protein termed MAP-1 has recently been identified. This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed. It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo. It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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