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Osenses
MAP2 Polyclonal Antibody
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图: 1 / 12
MAP2 Antibody (OSM00036G-500UG) in IHC (P)
Immunohistochemistry analysis of paraffin sections of mouse spinal cord. The animal was perfused using Autoperfuser at a pressure of 130 mmHg with 300 mL 4% FA before being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Osenses rabbit anti Gp combined with HRP polymer from Leica following m... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
OSM00036G-500UG
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from aa region 350-400 of mouse MAP2 conjugated to blue carrier protein was used as the antigen
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
Conc. Not Determined
规格
500 µg
纯化类型
Ammonium sulfate precipitation
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat.
Specificity of this antibody: MAP-2.
靶标信息
MAP2 (Microtubule Associated Protein 2) exists in two high molecular weight forms (MAP2a & MAP2b) and a low molecular weight form. The expression of MAP2 is developmentally regulated and its multiple forms arise by alternative splicing of a single gene. MAP2 is involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dendrites, implicating a role in determining and stabilizing dendritic shape during neuron development. MAP2 is useful in studies of neuron structure in normal and malignant brain tissue as well as in degenerative diseases such as Alzheimer's Disease (AD).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: AC091465.1; DKFZp686I2148; MAP 2; map-2a; map2ab; microtubule-associated protein 2C; OTTHUMP00000163916; OTTHUMP00000208143; unnamed protein product
基因别名: G1-397-34; MAP-2; MAP2R; Mtap-2; Mtap2; repro4
UniProt ID: (Mouse) P20357, (Rat) P15146
Entrez Gene ID: (Mouse) 17756, (Rat) 25595
microtubule cytoskeleton organization
microtubule bundle formation
negative regulation of microtubule depolymerization
axonogenesis
dendrite development
central nervous system neuron development
establishment of cell polarity
negative regulation of axon extension
negative regulation of microtubule polymerization
neuron projection development
regulation of protein localization
dendrite morphogenesis
regulation of microtubule-based movement
positive regulation of anterograde dense core granule transport
regulation of organelle transport along microtubule
regulation of neurofibrillary tangle assembly
positive regulation of anterograde synaptic vesicle transport
response to estradiol
response to progesterone
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
