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Proteintech
MARK1 Polyclonal Antibody
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产品信息
21552-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
MARK1 Fusion Protein Ag16225 (506-611 aa encoded by BC113869)
偶联物
形式
Liquid
浓度
0.36 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: VCERTTDRY VALQNGKDSS LTEMSVSSIS SAGSSVASAV PSARPRHQKS MSTSGHPIKV TLPTIKDGSE AYRPGTTQRV PAASPSAHSI STATPDRTRF PRGSSSR (506-611 aa encoded by BC113869 )
靶标信息
MARK1 (MARK) is a serine/threonine kinase which is involved in cytoskeletal organization and biogenesis. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. MARK1 is involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ELKL motif serine-threonine protein kinase 3; ELKL motif serine/threonine-protein kinase 3; MAP/microtubule affinity-regulating kinase 1; MARK1; mark1 {ECO:0000312|RGD:619882}; Par-1c; PAR1 homolog c; Serine/threonine-protein kinase MARK1
基因别名: AW491150; B930025N23Rik; Emk3; KIAA1477; MARK; MARK1; mKIAA1477; mPar-1c; Par-1c; Par1c
UniProt ID: (Human) Q9P0L2, (Mouse) Q8VHJ5, (Rat) O08678
Entrez Gene ID: (Human) 4139, (Mouse) 226778, (Rat) 117016
magnesium ion binding
phosphatidylserine binding
protein serine/threonine kinase activity
ATP binding
phosphatidylinositol-4,5-bisphosphate binding
tau-protein kinase activity
phosphatidic acid binding
nucleotide binding
protein kinase activity
lipid binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
non-receptor serine/threonine protein kinase
