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Abnova
MAST2 Polyclonal Antibody, MaxPab™
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产品信息
H00023139-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
MAST2 (AAH15816.2, 1 a.a. approximately 792 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.49 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MRPRSRSLSP GRSPVSFDSE IIMMNHVYKE RFPKAHERSE SSEVAFVMQL VKKLMIIIAR PARLLECLEF DPEEFYHLLE AAEGHAKEGQ GIKCDIPRYI VSQLGLTRDP LEEMAQLSSC DSPDTPETDD SIEGHGASLP SKKTPSEEDF ETIKLISNGA YGAVFLVRHK STRQRFAMKK INKQNLILRN QIQQAFVERD ILTFAENPFV VSMFCSFDTK RHLCMVMEYV EGGDCATLLK NIGALPVDMV RLYFAETVLA LEYLHNYGIV HRDLKPDNLL ITSMGHIKLT DFGLSKMGLM SLTTNLYEGH IEKDAREFLD KQVCGTPEYI APEVILRQGY GKPVDWWAMG IILYEFLVGC VPFFGDTPEE LFGQVISDEI VWPEGDEALP PDAQDLTSKL LHQNPLERLG TGSAYEVKQH PFFTGLDWTG LLRQKAEFIP QLESEDDTSY FDTRSERYHH MDSEDEEEVS EDGCLEIRQF SSCSPRFNKV YSSMERLSLL EERRTPPPTK RSLSEEKEDH SDGLAGLKGR DRSWVIGSPE ILRKRLSVSE SSHTESDSSP PMTVRRRCSG LLDAPRFPEG PEEASSTLRR QPQEGIWVLT PPSGEGVSGP VTEHSGEQRP KLDEEAVGRS SGSSPAMETR GRGTSQLAEG ATAKAISDLA VRRARHRLLS GDSTEKRTAR PVNKVIKSAS ATALSLLIPS EHHTCSPLAS PMSPHSQSSN PSSRDSSPRS MASPCGPFAS TWVTPMSTPC TIWCGTWRME VRPVRQGFVK VTSSPMSMGN LCMAWCTRRW WS
靶标信息
Syntrophin is an adapter protein that functions to bind certain signaling molecules to the dystrophin-associated protein complex. This complex connects the extracellular matrix to the intracellular cytoskeleton for construction and maintenance of the postsynaptic structures in the neuromuscular junction and the central nervous system. Microtubule-associated serine/threonine-protein kinase 2 (MAST205) is a testis-specific, cytoplasmic protein that functions in a multi-protein complex in the maturation of spermatids. MAST205 is involved in linking the dystrophin/utrophin network with microtubule filaments via Syntrophin. By forming a complex with TRAF6, MAST205 regulates lipopolysaccharide-induced IL-12 synthesis in macrophages. This leads to the inhibition of TRAF6 NF-kappa-B activation. Two isoforms exist for MAST205 due to alternative splicing. Isoform 1 represents the full length protein, while isoform 2 lacks the residues 327-396 and 1091-1113. The N-terminus of MAST205 must be phosphorylated in order for ubiquitination to occur at the same site. This ubiquitination leads to the degradation of MAST205 via proteasome-mediated proteolysis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: microtubule associated testis specific serine/threonine protein kinase; Microtubule-associated serine/threonine-protein kinase 2
基因别名: KIAA0807; MAST2; MAST205; MTSSK
UniProt ID: (Human) Q6P0Q8
Entrez Gene ID: (Human) 23139
