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Invitrogen
MBNL3 Isoform G Polyclonal Antibody
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产品信息
PA5-21836
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human MBNL3. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
0.92 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: 293T, A431, HeLaS3, HepG2, Molt-4, Raji.
Predicted reactivity: Mouse (86%), Rat (87%), Bovine (87%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
MBNL3 (Muscleblind-like protein 3) is an RNA-binding protein involved in the regulation of alternative splicing. The gene encodes several isoforms, including MBNL3 isoform G, which has distinct roles in RNA metabolism and splicing. MBNL3 isoform G contains functional domains necessary for RNA binding and splicing regulation, which are separate from its RNA-binding zinc finger domains. The expression of MBNL3 is particularly noted in proliferating cells where it can inhibit the transcription of muscle-specific genes, thereby impacting myogenesis. This isoform has also been implicated in the regulation of muscle regeneration; knockout models of MBNL3 show impaired muscle regeneration and delayed response to injury. The nuanced regulation by MBNL3 isoform G suggests its importance in muscle biology and its involvement in RNA processing complexities that underpin muscle development and repair.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cys3His CCG1-required protein; muscleblind-like 3; Muscleblind-like protein 3; muscleblind-like splicing regulator 3; Muscleblind-like X-linked protein; Protein HCHCR; RP5-842K24.3
基因别名: CHCR; MBLX; MBLX39; MBNL3; MBXL
UniProt ID: (Human) Q9NUK0
Entrez Gene ID: (Human) 55796
