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Invitrogen
MBP Polyclonal Antibody
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FIGURE: 1 / 10
MBP Antibody (PA1-10008) in ICC/IF
Immunofluorescent analysis of MBP cortical neuron-glial cell culture. The culture was prepared from an E20 rat and stained using an MBP polyclonal antibody (Product # PA1-10008) at a dilution of 1:2,000 as seen in red, and with DAPI staining the nuclear DNA in blue. The antibody stains developing oligodendrocytes, cells, that form myelin around axons in the central nerve system.
Product Details
PA1-10008
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Pig,
Rat
Published species
C. elegans,
Mouse,
Rat
Host/Isotype
Chicken
/ IgY
Class
Polyclonal
Type
Antibody
Immunogen
Purified myelin basic protein isolated from bovine brain.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In Western blot using rat spinal cord whole tissue homogenates, this antibody detects all isotypes of MPB, resulting in bands at ~21.5kDa, 18.5kDa, 17kDa and 14kDa. |Stable at 4°C for at least one year.
Target Information
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 20 kDa microtubule-stabilizing protein; golli mbp; Golli-Mbp; myelin basic protein; Golli-Mbp; myelin basic protein; myelin basic protein S; MBP; MBP S; MGC99675; microtubule-stabilizing protein; Myelin A1 protein; Myelin basic protein; myelin basic protein Golli-mbp; myelin basic protein S; myelin deficient; Myelin membrane encephalitogenic protein; shiverer
Gene Aliases: C76307; golli-mbp; Hmbpr; MBP; Mbps; mld; R75289; Shi
UniProt ID: (Human) P02686, (Rat) P02688, (Mouse) P04370
Entrez Gene ID: (Human) 4155, (Pig) 414286, (Bovine) 618684, (Rat) 24547, (Mouse) 17196
immune response
chemical synaptic transmission
central nervous system development
aging
axon ensheathment
response to toxic substance
substantia nigra development
response to progesterone
response to tumor necrosis factor
myelination
response to mercury ion
negative regulation of axonogenesis
membrane organization
response to fatty acid
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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