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Invitrogen
MBTPS1 Polyclonal Antibody
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FIGURE: 1 / 2
MBTPS1 Antibody (PA5-77103) in WB
Western blot was performed using Anti-MBTPS1 Polyclonal Antibody (Product # PA5-77103) and a ~130kDa band corresponding to Membrane-bound transcription factor site-1 protease was observed across cell lines and tissues tested . Membrane enriched extracts (30 µg lysate) of SK-O-V3 (Lane 1), SK-O-V3 treated with 1X PTI for 4h (Lane 2), A549 (Lane 3), A549 treated with 1X PTI for 4h (Lane 4), MCF7 (Lane 5), MCF7 treated with 1X PTI for 4h (Lane 6), HeLa (Lane 7), U-87 MG (Lane 8) Mouse Liver (Lane 9), Mouse Spleen (Lane 10) were electrophorese... View More
Product Details
PA5-77103
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant full length Human MBTPS1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Endopeptidase S1P; membrane-bound transcription factor peptidase, site 1; membrane-bound transcription factor protease, site 1; Membrane-bound transcription factor site-1 protease; proprotein convertase subtilisin/kexin type 8; S1P endopeptidase; site-1 protease; SKI-1; Sterol-regulated luminal protease; subtilisin kexin isozyme 1; Subtilisin/kexin isozyme 1; subtilisin/kexin isozyme SKI-1; subtilisin/kexin isozyme-1; Subtilisin/kexin-isozyme 1
Gene Aliases: 0610038M03Rik; AV003995; KIAA0091; MBTPS1; mKIAA0091; PCSK8; S1P; SKI-1; SKI1
UniProt ID: (Human) Q14703, (Mouse) Q9WTZ2
Entrez Gene ID: (Human) 8720, (Mouse) 56453
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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