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Proteintech
MCM4 Monoclonal Antibody (2H2A1), CoraLite® Plus 488
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MCM4 Antibody (CL488-67103) in Flow
1X10^6 HeLa cells were intracellularly stained with 0.4 µg CoraLite® Plus 488 Anti-Human MCM4 (CL488-67103, Clone:2H2A1) (red), or 0.4 µg Mouse IgG2b Isotype Control (CL488-66360-3, Clone: K11B8C4B5) (blue). Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011).
产品信息
CL488-67103
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
2H2A1
抗原
Recombinant protein
偶联物
激发/发射光谱
493/522 nm
形式
Liquid
纯化类型
Protein A
保存液
PBS with 50% glycerol, 0.5% BSA
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Immunogen sequence: SKSQLLQYVY NLVPRGQYTS GKGSSAVGLT AYVMKDPETR QLVLQTGALV LSDNGICCID EFDKMNESTR SVLHEVMEQQ TLSIAKAGII CQLNARTSVL AAANPIESQW NPKKTTIENI QLPHTLLSRF DLIFLMLDPQ DEAYDRRLAH HLVALYYQSE EQAEEELLDM AVLKDYIAYA HSTIMPRLSE EASQALIEAY VDMRKIGSSR GMVSAYPRQL ESLIRLAEAH AKVRLSNKVE AIDVEEAKRL HREALKQSAT DPRTGIVDIS ILTTGMSATS RKRKEELAEA LKKLILSKGK TPALKYQQLF EDIRGQSDIA ITKDMFEEAL RALADDDFLT VTGKT
靶标信息
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CDC21 homolog; DNA replication licensing factor MCM4; homolog of S. pombe cell devision cycle 21; mini chromosome maintenance deficient 4 homolog; minichromosome maintenance deficient 4; minichromosome maintenance deficient 4 homolog; P1-CDC21
基因别名: 19G; AI325074; AU045576; CDC21; CDC54; hCdc21; mcdc21; MCM4; Mcmd4; mKIAA4003; NKCD; NKGCD; P1-CDC21
UniProt ID: (Human) P33991, (Mouse) P49717
Entrez Gene ID: (Human) 4173, (Rat) 29728, (Mouse) 17217
