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Invitrogen
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PA1-31306 detects MCM8 from human samples.
PA1-31306 has been successfully used in immunoprecipitation, Western blot applications.
The PA1-31306 immunogen is: Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) representing a portion of MCM8 encoded within exon 2 (Human).
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。