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Proteintech
MCRS1 Monoclonal Antibody (2H10E10)
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产品信息
60215-1-IG
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
2H10E10
抗原
MCRS1 Fusion Protein Ag1904 (1-462 aa encoded by BC011794)
偶联物
形式
Liquid
浓度
1.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MDKDSQGLL DSSLMASGTA SRSEDEESLA GQKRASSQAL GTIPKRRSSS RFIKRKKFDD ELVESSLAKS STRAKGASGV EPGRCSGSEP SSSEKKKVSK APSTPVPPSP APAPGLTKRV KKSKQPLQVT KDLGRWKPAD DLLLINAVLQ TNDLTSVHLG VKFSCRFTLR EVQERWYALL YDPVISKLAC QAMRQLHPEA IAAIQSKALF SKAEEQLLSK VGSTSQPTLE TFQDLLHRHP DAFYLARTAK ALQAHWQLMK QYYLLEDQTV QPLPKGDQVL NFSDAEDLID DSKLKDMRDE VLEHELMVAD RRQKREIRQL EQELHKWQVL VDSITGMSSP DFDNQTLAVL RGRMVRYLMR SREITLGRAT KDNQIDVDLS LEGPAWKISR KQGVIKLKNN GDFFIANEGR RPIYIDGRPV LCGSKWRLSN NSVVEIASLR FVFLINQDLI ALIRAEAAKI TPQ (1-462 aa encoded by BC011794)
靶标信息
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U) (PubMed:16571602). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 58 kDa microspherule protein; cell cycle-regulated factor (78 kDa); Cell cycle-regulated factor p78; INO80 complex subunit J; INO80 complex subunit Q; MCRS2; Microspherule protein 1; nucleolar protein
基因别名: C78274; ICP22BP; INO80Q; MCRS1; MCRS2; MSP58; P78
UniProt ID: (Human) Q96EZ8, (Mouse) Q99L90
Entrez Gene ID: (Human) 10445, (Rat) 300222, (Mouse) 51812
biological_process
histone H4-K5 acetylation
histone H4-K8 acetylation
histone H4-K16 acetylation
DNA repair
DNA recombination
transcription, DNA-templated
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
chromatin modification
cellular protein modification process
positive regulation of protein localization to nucleolus
