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Invitrogen
MDN1 Polyclonal Antibody
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产品信息
PA5-56225
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.30 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: QINEEISHLI SFCLYHTPVT PQELRDLWSL LHHQKVSPEE ITSLWSELFN SMFMSFWSST VTTNPEYWLM WNPLPGMQQR EAPKSVLDST LKG
Highest antigen sequence identity to the following orthologs: Mouse - 62%, Rat - 66%.
靶标信息
Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus. At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm. Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Dynein-related AAA-ATPase MDN1; MDN1, midasin homolog; MIDAS-containing protein; Midasin
基因别名: KIAA0301; MDN1; Rea1
UniProt ID: (Human) Q9NU22
Entrez Gene ID: (Human) 23195
