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Proteintech
MEPCE Polyclonal Antibody
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产品信息
14917-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
MEPCE Fusion Protein Ag6733 (340-689 aa encoded by BC000556)
偶联物
形式
Liquid
浓度
0.67 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: SGSLSAPPA ASVISAPPSS SSRHRKRRRT SSKSEAGARG GGQGSKEKGR GSWGGRHHHH HPLPAAGFKK QQRKFQYGNY CKYYGYRNPS CEDGRLRVLK PEWFRGRDVL DLGCNVGHLT LSIACKWGPS RMVGLDIDSR LIHSARQNIR HYLSEELRLP PQTLEGDPGA EGEEGTTTVR KRSCFPASLT ASRGPIAAPQ VPLDGADTSV FPNNVVFVTG NYVLDRDDLV EAQTPEYDVV LCLSLTKWVH LNWGDEGLKR MFRRIYRHLR PGGILVLEPQ PWSSYGKRKT LTETIYKNYY RIQLKPEQFS SYLTSPDVGF SSYELVATPH NTSKGFQRPV YLFHKARSPS H (340-689 aa encoded by BC000556)
靶标信息
S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 7SK snRNA methylphosphate capping enzyme; Bicoid-interacting protein 3 homolog; Bin3 homolog; bin3, bicoid-interacting 3, homolog; FLJ20257; MePCE
基因别名: BCDIN3; MEPCE
UniProt ID: (Human) Q7L2J0
Entrez Gene ID: (Human) 56257
