Bioss

MHC class 1 antigen B 15 Polyclonal Antibody

Name: MHC class 1 antigen B 15 Polyclonal Antibody
Brand: Bioss
SKU: BS-4120R

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

Immunogen image

Immunogen Image MHC class 1 antigen B 15 Polyclonal Antibody

产品信息

BS-4120R

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

免疫组化（石蜡） (IHC (P))

Assay-dependent

免疫组化（冰冻） (IHC (F))

1:100-1:500

免疫细胞化学 (ICC/IF)

1:100-1:500

酶联免疫吸附实验 (ELISA)

1:500-1:1,000

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from human MHC class I antigen B 15, amino acids 65-130.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

内含物

0.02% ProClin 300

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

HLA-B15 (B15) is an HLA-B serotype. The serotype identifies the B15 gene-allele protein products of HLA-B. B15 is a broad antigen can be subdivided into several split antigens that are often used in characterization. These are B62, B63, B70, B71, B72, B75, B76, B77. B15 is the largest allele grouping for any known human autosomal locus, identified as of August 2008 there are more than 150 alleles and approximately 140 amino acid sequence variants from those gene products. Some of these alleles are discussed below. HLA-B15 allele 1502 is associated with the severe skin conditions Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) caused by carbamazepine drug sensitivity in East Asians.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: class I MHC, HLA-B antigen; epididymis secretory protein Li 83; histocompatibility antigen; HLA -B; HLA B-40011; HLA B44; HLA class I antigen HLA-B; HLA class I histocompatibility antigen, B alpha chain; HLA class I histocompatibility antigen, B-47 alpha chain; HLA class I histocompatibility antigen, B-50 alpha chain; HLA class I histocompatibility antigen, B-82 alpha chain; HLA locus; HLA molecule; HLA-B; HLA-B alpha chain; HLA-B alpha chain (B*2706); HLA-B alpha chain (B*5002); HLA-B alpha-chain; HLA-B35; HLA-B35 antigen; HLA-Bw50 antigen; Human leukocyte antigen B; hypothetical protein; lecocyte antigen B; Leukocyte Antigen; leukocyte antigen class I-B; Leukoocyte Antigen; lymphocyte antigen; major histocompatability complex B antigen; MHC antigen; MHC class 1 antigen; MHC class I alpha chain; MHC class I anitgen; MHC class I antigen B*47; MHC class I antigen B*50; MHC class I antigen B*82; MHC class I antigen GN00104; MHC class I antigen HLA-B alpha chain; MHC class I antigen HLA-B heavy chain; MHC class I antigen SHCHA; MHC class I antigene; MHC class I human leukocyte antigen; MHC class I molecule; MHC class I protein; MHC class II antigen; MHC class l antigen; MHC classI antigen; MHC HLA-B cell surface glycoprotein; MHC HLA-B transmembrane glycoprotein; MHC HLA-B27-HS; MHC HLA-B27d; MHC HLA-B39N; truncated class I antigen; truncated MHC class I antigen

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基因别名: AS; B-4901; B-5001; Bw-47; Bw-50; HEL-S-83; HLA-B; HLA-B*45ZJ; HLA-B-3506; HLA-B-3905; HLA-B-5502; HLA-B-5602; HLA-B15; HLA-B39; HLA-B49; HLA-B50; HLA-B55; HLA-B59; HLA-B61; HLA-Cw; HLA-DRB1; HLAB; SPDA1

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UniProt ID: (Human) Q29678

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Entrez Gene ID: (Human) 3106

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功能

antigen binding peptide antigen binding major histocompatibility complex protein

参与通路

antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent viral process antigen processing and presentation regulation of immune response interferon-gamma-mediated signaling pathway type I interferon signaling pathway