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Invitrogen
MINA53 Recombinant Rabbit Monoclonal Antibody (4E6G6)
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MINA53 Antibody (MA5-38013) in WB
Western blot analysis of MINA53 in extracts of various cell lines. Samples were incubated with MINA53 Monoclonal antibody (Product # MA5-38013) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
MA5-38013
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
4E6G6
抗原
A synthetic peptide corresponding to a sequence within amino acids 350-450 of human RIOX2/MINA53 (Q8IUF8)
偶联物
形式
Liquid
浓度
2.2 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: BxPC-3, Mouse testis, Rat testis
Immunogen sequence: LSTPGGKLPR LDSVVRLQFK DHIVLTVLPD QDQSDEAQEK MVYIYHSLKN SRETHMMGNE EETEFHGLRF PLSHLDALKQ IWNSPAISVK DLKLTTDEEK E
靶标信息
MINA is nuclear localized, myc-inducible protein that is thought to play a role in mammalian cell proliferation. Treatment of cancer cells lines such as the colon cancer cell line SW680 with siRNA against MINA inhibits cell growth, demonstrating that MINA may be a potential therapeutic target. MINA regulates several genes related to cell adhesion and metabolism that have also been shown to be regulated by c-Myc, but also regulates other genes whose expression are not modulated by c-Myc such as EGFR, IL-6 and HGF. MINA has also been found to act as a repressor to IL-4 expression in T cells, indicating that it may also play a role in T cell differentiation and genetic variation in T helper type 2 bias.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 60S ribosomal protein L27a histidine hydroxylase; Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA; DKFZp762O1912; FLJ14393; Histone lysine demethylase MINA; MINA; mina {ECO:0000312|RGD:708521}; Mina-53; mineral dust induced gene protein; Mineral dust-induced gene protein; MYC-induced nuclear antigen; myc-induced nuclear antigen, 53 kDa; Nucleolar protein 52; Protein mina53; Ribosomal oxygenase 2; Ribosomal oxygenase MINA; ROX
基因别名: 1810047J07Rik; 2410057H13Rik; 3830408E23Rik; AI449204; MDIG; MINA; MINA53; NO52; RIOX2; ROX
UniProt ID: (Human) Q8IUF8, (Mouse) Q8CD15, (Rat) Q8CFC1
Entrez Gene ID: (Human) 84864, (Mouse) 67014, (Rat) 266670
transcriptional repressor activity, RNA polymerase II transcription factor binding
iron ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
sulfonate dioxygenase activity
oxidoreductase activity
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
hypophosphite dioxygenase activity
DNA-N1-methyladenine dioxygenase activity
metal ion binding
dioxygenase activity
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
peptidyl-amino acid modification
ribosome biogenesis
post-translational protein modification
negative regulation of transcription, DNA-templated
oxidation-reduction process
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
cell proliferation
regulation of cell proliferation
