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Proteintech
MIOS Polyclonal Antibody
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产品信息
20826-1-AP
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
MIOS Fusion Protein Ag14802 (526-875 aa encoded by BC005883)
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: AVALFNLDI RRAIQILNEG ASSEKGDLNL NVVAMALSGY TDEKNSLWRE MCSTLRLQLN NPYLCVMFAF LTSETGSYDG VLYENKVAVR DRVAFACKFL SDTQLNRYIE KLTNEMKEAG NLEGILLTGL TKDGVDLMES YVDRTGDVQT ASYCMLQGSP LDVLKDERVQ YWIENYRNLL DAWRFWHKRA EFDIHRSKLD PSSKPLAQVF VSCNFCGKSI SYSCSAVPHQ GRGFSQYGVS GSPTKSKVTS CPGCRKPLPR CALCLINMGT PVSSCPGGTK SDEKVDLSKD KKLAQFNNWF TWCHNCRHGG HAGHMLSWFR DHAECPVSAC TCKCMQLDTT GNLVPAETVQ P (526-875 aa encoded by BC005883)
靶标信息
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: FLJ20323; GATOR2 complex protein MIOS; H_DJ1159O04.1; Missing oocyte meiosis regulator homolog; missing oocyte, meiosis regulator, homolog; WD repeat-containing protein mio; WUGSC:H_DJ1159O04.1
基因别名: MIO; MIOS; RGD1308432; Sea4
UniProt ID: (Human) Q9NXC5
Entrez Gene ID: (Human) 54468, (Rat) 362324
