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Invitrogen
MKP3 Polyclonal Antibody
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产品信息
PA1-28321
产品规格
宿主/亚型
Chicken
/ IgY
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide, corresponding to amino acids 135-280 of Human DUSP6a.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
PA1-28321 detects DUSP6a from human, mouse, rat samples.
PA1-28321 has been successfully used in Western blot applications. Detects a band of approximately 60kDa in an E-coli fusion protein sample (predicted molecular weight: 42kDa).
The PA1-28321 immunogen is synthetic peptide, corresponding to amino acids 135-280 of Human DUSP6a.
靶标信息
DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associatedwith cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Twotranscript variants encoding different isoforms have been found for the DUSP6 gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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