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Proteintech
MLK4 Polyclonal Antibody
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产品信息
24395-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
MLK4 Fusion Protein Ag18904 (689-1036 aa encoded by BC136649)
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: WEEAASANA ATVSIEMTPT NSLSRSPQRK KTESALYGCT VLLASVALGL DLRELHKAQA AEEPLPKEEK KKREGIFQRA SKSRRSASPP TSLPSTCGEA SSPPSLPLSS ALGILSTPSF STKCLLQMDS EDPLVDSAPV TCDSEMLTPD FCPTAPGSGR EPALMPRLDT DCSVSRNLPS SFLQQTCGNV PYCASSKHRP SHHRRTMSDG NPTPTGATII SATGASALPL CPSPAPHSHL PREVSPKKHS TVHIVPQRRP ASLRSRSDLP QAYPQTAVSQ LAQTACVVGR PGPHPTQFLA AKERTKSHVP SLLDADVEGQ SRDYTVPLCR MRSKTSRPSI YELEKEFLS (689-1036 aa encoded by BC136649)
靶标信息
MLK4 or mixed lineage kinase 4 belongs to the superfamily of MAP kinase kinases (MAP3K1) which contain both ser/thr and tyr kinases activity in their catalytic domains. The structure of this kinase family incorporates an N-terminal Src homology (SH3) domain, followed by the kinase domain, a leucine zipper region, and a CDC42 /RAC -interactive binding (CRIB) motif, but divergent C-terminal regions. MLK4 is highly expressed in kidney and pancreas. MLK4 is a negative regulator of TLR4 and does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Mitogen-activated protein kinase kinase kinase 21; Mitogen-activated protein kinase kinase kinase MLK4; Mixed lineage kinase 4; MLK4; similar to Mixed lineage kinase 4
基因别名: dJ862P8.3; KIAA1804; MAP3K21; mKIAA1804; MLK4
UniProt ID: (Mouse) Q8VDG6, (Human) Q5TCX8
Entrez Gene ID: (Mouse) 234878, (Human) 84451, (Rat) 307950
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase kinase activity
protein tyrosine kinase activity
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein binding
protein homodimerization activity
non-receptor serine/threonine protein kinase
