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Proteintech
MMP3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
17873-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse,
Rabbit,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
MMP3 Fusion Protein Ag12359 (26-477 aa encoded by BC074869)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.2 mg/mL
规格
30 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: GEDTSMNLV QKYLENYYDL EKDVKQFVRR KDSGPVVKKI REMQKFLGLE VTGKLDSDTL EVMRKPRCGV PDVGHFRTFP GIPKWRKTHL TYRIVNYTPD LPKDAVDSAV EKALKVWEEV TPLTFSRLYE GEADIMISFA VREHGDFYPF DGPGNVLAHA YAPGPGINGD AHFDDDEQWT KDTTGTNLFL VAAHEIGHSL GLFHSANTEA LMYPLYHSLT DLTRFRLSQD DINGIQSLYG PPPDSPETPL VPTEPVPPEP GTPANCDPAL SFDAVSTLRG EILIFKDRHF WRKSLRKLEP ELHLISSFWP SLPSGVDAAY EVTSKDLVFI FKGNQFWAIR GNEVRAGYPR GIHTLGFPPT VRKIDAAISD KEKNKTYFFV EDKYWRFDEK RNSMEPGFPK QIAEDFPGID SKIDAVFEEF GFFYFFTGSS QLEFDPNAKK VTHTLKSNSW LNC (26-477 aa encoded by BC074869)
靶标信息
MMP3 (stromelysin-1) belongs to the peptidase M10A subfamily. It is secreted in its pro-protein form, and is activated by extracellular proteinase cleavage. MMP3 is capable of binding to zinc and calcium ions, and has metallo-endopeptidase activity. The active enzyme degrades collagen, gelatin, fibronectin, and laminin. It is involved in normal cellular processes such as wound repair and tissue remodeling. Mutations in the gene can result in coronary heart disease 6.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: EC 3.4.24.17; matrix metallo protease; matrix metalloproteinase 3; matrix metalloproteinase 3 (stromelysin 1, progelatinase); matrix metalloproteinase-3; MMP; MMPs; progelatinase; proteoglycanase; PTR1 protein; Stromelysin1; transin-1; Transin1; unnamed protein product
基因别名: CHDS6; EMS-2; MMP-3; SL-1; SLN-1; SLN1; STMY; STMY1; STR-1; STR1
UniProt ID: (Human) P08254, (Mouse) P28862
Entrez Gene ID: (Human) 4314, (Mouse) 17392, (Rat) 171045
proteolysis
protein catabolic process
extracellular matrix organization
regulation of cell migration
positive regulation of cell migration
collagen catabolic process
positive regulation of protein complex assembly
cellular response to reactive oxygen species
negative regulation of protein kinase B signaling
cellular response to amino acid stimulus
cellular response to UV-A
negative regulation of reactive oxygen species metabolic process
response to hypoxia
female pregnancy
response to mechanical stimulus
response to estradiol
response to lipopolysaccharide
response to cytokine
response to tumor necrosis factor
response to amino acid
response to interleukin-1
cellular response to interleukin-1
cellular response to cell-matrix adhesion
extracellular matrix disassembly
cellular response to lipopolysaccharide
cellular response to nitric oxide
regulation of neuroinflammatory response
response to amyloid-beta
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