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Invitrogen
MMP3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-82318
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.1 mg/mL
规格
10 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MYPLYHSLTD LTRFRLSQDD INGIQSLYGP PPDSPETPLV PTEPVPPEPG TPANCDPALS FDAVSTLRGE ILIFKDRHFW RKSLRKLEPE LHLISSFWPS LPSGVDAAYE VTSKDLVFIF KGNQFWAI
Highest antigen sequence indentity to the following orthologs: Rat - 70%, Mouse - 70%.
靶标信息
MMP3 (stromelysin-1) belongs to the peptidase M10A subfamily. It is secreted in its pro-protein form, and is activated by extracellular proteinase cleavage. MMP3 is capable of binding to zinc and calcium ions, and has metallo-endopeptidase activity. The active enzyme degrades collagen, gelatin, fibronectin, and laminin. It is involved in normal cellular processes such as wound repair and tissue remodeling. Mutations in the gene can result in coronary heart disease 6.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: EC 3.4.24.17; matrix metallo protease; matrix metalloproteinase 3 (stromelysin 1, progelatinase); MMP; MMPs; proteoglycanase; Stromelysin1; transin-1; Transin1; unnamed protein product
基因别名: CHDS6; MMP-3; SL-1; STMY; STMY1; STR1
UniProt ID: (Human) P08254
Entrez Gene ID: (Human) 4314
proteolysis
extracellular matrix disassembly
protein catabolic process
extracellular matrix organization
collagen catabolic process
positive regulation of protein complex assembly
cellular response to reactive oxygen species
negative regulation of protein kinase B signaling
cellular response to lipopolysaccharide
cellular response to UV-A
cellular response to nitric oxide
regulation of neuroinflammatory response
response to amyloid-beta
negative regulation of reactive oxygen species metabolic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
